GW28-e0330 Cardio-protective effects of Qishen Granule on sarcoplasmic reticulum Ca2+ handling in heart failure rats
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چکیده
منابع مشابه
Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a
We previously found that luteolin (Lut) appeared to improve the contractility of cardiomyocytes during ischemia/reperfusion in rats. The enhancement was associated with the alteration in sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a). This finding prompted us to consider if the mechanism worked in heart failure (HF). We studied the regulation of SERCA2a by Lut in failing cardiomyocytes and int...
متن کاملCa2+-ATPase activity and Ca2+ uptake by sarcoplasmic reticulum in fish heart: effects of thermal acclimation.
This study was designed to compare the activities of sarcoplasmic (SR) Ca2+-ATPase and Ca2+ uptake in fish and mammalian hearts and to determine whether thermal acclimation has any effect on the function of the cardiac SR in fish. To this end, we measured thapsigargin-sensitive Ca2+-ATPase activity and thapsigargin-inhibitable Ca2+ uptake velocity in crude cardiac homogenates of newborn and adu...
متن کاملSarcoplasmic Reticulum Ca Homeostasis and Heart Failure
Heart function vitally relies on precisely controlled intracellular Ca homeostasis during each cardiac cycle. Abnormalities in Ca regulation cause contractile dysfunction and arrhythmias under different pathological conditions including heart failure (HF). Playing a particularly important role in heart contraction is the sarcoplasmic reticulum (SR). In adult ventricular myocytes, the SR forms a...
متن کاملChanges in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
ii Acknowledgements iv List of Tables viii List of Figures xi Chapter 1: Introduction
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2017
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2017.07.198